Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase.
نویسندگان
چکیده
Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 92 شماره
صفحات -
تاریخ انتشار 2012